Neuroscience Exploring The Brain 4th Edition Pdf 49 [EXCLUSIVE]
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Our studies of opioid tolerance and dependence are also being conducted in wild-type animals. Our laboratory has discovered that the stress-induced increases in anxiety-like behavior are abolished in mice treated chronically with the MOR antagonist CTAP39,40,41, and that chronic treatment with the MOP receptor agonist DAMGO attenuates the reduction in the number of MOP receptors in the brain associated with repeated defeat stress42. These findings demonstrate that MOR signaling is essential for the development of anxiety-like behavior induced by chronic social defeat stress and that MOR signaling is attenuated by repeated treatment with the MOP receptor agonist DAMGO. The chronic selective MOP agonist DAMGO has potential for the treatment of anxiety43,44,45. Our findings that the chronic agonist treatment of MOP leads to an attenuation of the reduction in MOP expression induced by social defeat suggest the use of MOP agonists in the treatment of depression and anxiety.
The individual differences in our emotional reactions, which are influenced by our internal emotional state and the external environment, can give us insight into the mechanisms of brain and behavioral disorders that affect our lives.
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One of the drawbacks to this approach was that we needed to recompile every time we made even a small change to the code. This slowed everything else we were doing down and because we couldn't always have someone waiting for the application to finish building. 827ec27edc